Modelling tuberculous meningitis in zebrafish using Mycobacterium marinum
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چکیده
منابع مشابه
Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum
Tuberculous meningitis (TBM) is one of the most severe extrapulmonary manifestations of tuberculosis, with a high morbidity and mortality. Characteristic pathological features of TBM are Rich foci, i.e. brain- and spinal-cord-specific granulomas formed after hematogenous spread of pulmonary tuberculosis. Little is known about the early pathogenesis of TBM and the role of Rich foci. We have adap...
متن کاملESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish.
ESX-5 is a mycobacterial type VII protein secretion system responsible for transport of numerous PE and PPE proteins. It is involved in the induction of host cell death and modulation of the cytokine response in vitro. In this work, we studied the effects of ESX-5 in embryonic and adult zebrafish using Mycobacterium marinum. We found that ESX-5-deficient M. marinum was slightly attenuated in ze...
متن کاملHuman Tuberculous Meningitis Caused by Mycobacterium caprae
INTRODUCTION Tuberculous meningitis (TM) causes substantial morbidity and mortality in humans. Human TM has been known to be induced by bacteria from the Mycobacterium tuberculosis complex (MTBC), such as M. tuberculosis and M. bovis. CASE PRESENTATION We describe a case of meningitis treated with fosfomycin, which showed partial effectiveness in an 80-year-old patient. After a lethal myocard...
متن کاملInvasive Mycobacterium marinum Infections
1. Ashford RW, Crewe W. The parasites of Homo sapiens: an annotated checklist of the protozoa, helminths and arthropods for which we are home. London: Taylor and Francis; 2003. 2. Haydon DT, Cleaveland S, Taylor LH, Laurenson MK. Identifying reservoirs of infection: a conceptual and practical challenge. Emerg Infect Dis 2002;8:1468–73. 3. Ashford RW. What it takes to be a reservoir host. Belgia...
متن کاملTuberculous Meningitis
This is a brief review of the cases of tuberculous meningitis treated at Ham Green Hospital with streptomycin. Since 1948, seventy-seven cases have been admitted and of these thirty-five (45 per cent) are still living. For the purpose of this review seventeen cases are excluded?eight because they have been admitted too recently and nine, the earliest cases, either because they received quite in...
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2014
ISSN: 1754-8411,1754-8403
DOI: 10.1242/dmm.015453